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Last Updated: 06/06/2026
Harness Therapeutics
Cambridge
Founded 2020
RNA-based therapeutics targeting neurodegenerative disease mechanisms
Harness Therapeutics is a Cambridge-based biotech developing oligonucleotide therapeutics that exploit post-transcriptional regulation to achieve controlled upregulation of disease-relevant proteins in the CNS.
Its lead programme targets FAN1 nuclease in Huntington's disease to limit somatic DNA repeat expansion, with a second programme addressing TDP-43 pathology.
The company was established by Takeda Ventures and SV Health Investors' Dementia Discovery Fund and is based at the Babraham Research Campus.