Explore life science and biotech companies in Sheffield, including gene and cell therapy, laboratory instruments and industrial biotechnology.
Patient-derived mitochondrial screening for preclinical drug discovery
Mitotype Precision Labs is a contract research organisation providing patient-derived cellular assays for drug discovery and preclinical evaluation. Its screening services use fibroblasts, neurons and astrocytes to measure mitochondrial function, lysosomal biology and other disease-relevant cellular responses. The…
Life sciences and medtech industry association for Northern England
Medilink North of England is a not-for-profit membership organisation and specialist consultancy supporting life sciences, medtech, and health technology companies across Yorkshire, the North West, and the North East. As the founding member of the Medilink UK network, it provides innovation and commercialisation…
Directed evolution platform engineering microbes for industrial biomanufacturing
Evolutor is a biotechnology company developing directed evolution technologies to enhance microbial performance for industrial biomanufacturing. Its proprietary genetic toolbox links bacterial cell fitness to recombinant protein production rates, generating evolved production strains with substantially improved…
Precision fermentation platform for novel protein-based flavour ingredients
ReNewFood is an industrial biotech developing protein-based flavouring ingredients for the alternative food market using precision fermentation. Engineered microbial hosts serve as cell factories to produce flavour-active proteins, including molecules conferring meatiness, sweetness, and saltiness, identified through…
Metal-based antimicrobial drugs and antibiofilm coating compounds
MetalloBio is a University of Sheffield spin-out developing metal-based antimicrobial compounds against drug-resistant bacterial infections. Its KLS-1 series includes investigational antibacterial candidate KLS-116, designed to act against multidrug-resistant pathogens and biofilms. The KLS-2 series is being developed…
Benchtop single-molecule fluorescence instruments for life science research
Exciting Instruments develops accessible benchtop single-molecule fluorescence spectroscopy instruments and cloud-based analysis software. Its system enables researchers to perform single-molecule FRET and fluorescence correlation spectroscopy without specialist infrastructure, guided alignment, or custom coding. The…
Plant-derived PLA materials for high-performance and compostable plastics
Floreon is an industrial biotechnology and materials company developing high-performance plastics based on renewable polylactic acid (PLA). Its proprietary polymer formulations modify plant-derived PLA for improved toughness, heat resistance and processability. Commercial grades include flame-retardant Therma-Tech,…
siRNA gene therapies targeting root causes of ALS and frontotemporal dementia
Crucible Therapeutics Limited is a preclinical-stage biotechnology company developing siRNA-based gene therapies for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia caused by the C9orf72 gene mutation. Its therapeutic approach depletes the SRSF1 protein to suppress production of toxic dipeptide repeat…
Cell profiling and precision additives for biologic manufacturing
Silvia Bio is a University of Sheffield spin-out developing cell-profiling services and media additives for mammalian-cell biomanufacturing. Its platform identifies cellular bottlenecks limiting productivity and biologic product quality, then formulates bioreactor-compatible additives to address them without genetic…
Regenerative cell therapy for sensorineural hearing loss
Rinri Therapeutics is a clinical-stage biotech developing allogeneic regenerative cell therapies for sensorineural hearing loss, a condition affecting over 400 million people worldwide for which no disease-modifying treatment currently exists. Its lead programme, Rincell-1, is an otic neural progenitor cell therapy…
Automated cell culture platform and stem cell lines for biomanufacturing
Unicorn Biotechnologies is a Sheffield-based company developing automated cell culture instruments and stem cell line products for research and biomanufacturing applications. Its platform is a modular, closed-loop cell culture robot that standardises and scales cell culture workflows across drug discovery,…
Synthetic gene promoter platform for biologics and cell and gene therapy
SynGenSys is a synthetic biology company developing proprietary libraries of synthetic gene promoters and signal peptides designed to improve the yield, specificity, and reliability of recombinant protein expression. Its computational platform uses bioinformatics and AI to design novel promoters from first principles,…