Small molecule drug companies develop low-molecular-weight medicines designed to interact with specific biological targets. These compounds can often enter cells and may be formulated as oral or other conventional dosage forms across a wide range of therapeutic areas.
This category includes companies working on:
Browse 202 UK small molecule drug companies below.
AI-guided plant biosynthesis platform for novel therapeutic compounds
HotHouse Therapeutics is a drug discovery platform company that engineers plants as sustainable biofactories for pharmaceutical compound production. Using AI to design and…
Single-pill fixed-dose combinations for cardiometabolic disease
George Medicines is a late-stage biopharmaceutical company developing innovative single-pill, fixed-dose combination therapies for cardiometabolic diseases. Rather than pursuing…
Therapeutics targeting lysosomal dysfunction in neurodegeneration
Endlyz Therapeutics is a preclinical-stage biotechnology company developing small molecule modulators to restore endo-lysosomal function in Parkinson's disease and related…
Oral muscle-sparing small molecule therapies for obesity
Hawkhill Therapeutics is a pre-clinical biotechnology company developing oral, muscle-sparing therapeutics for obesity and metabolic health. Its programme targets a clinically…
Neuroactive therapeutics through genetic engineering of fungi and plants
Empyrean Neuroscience is a biopharma company that uses genetic engineering of fungi and plants to develop small molecule therapeutics for neuropsychiatric and neurologic…
Preclinical CRO delivering integrated drug discovery and development services
Selvita is a contract research organisation providing integrated drug discovery and development services to pharmaceutical and biotechnology companies. The company supports…
AI-driven drug discovery targeting necrosis and age-related disease
LinkGevity is a preclinical-stage biotechnology company developing anti-necrotic therapeutics for age-related and degenerative diseases. Founded in 2023 and based at Babraham…
Small-molecule anti-biofilm add-on therapy for antibiotic-resistant urinary tract infections
BioTryp Therapeutics is a UK-based drug discovery company developing small-molecule therapies that inhibit bacterial biofilm formation. The company's lead programme is an oral…
Small molecule therapies for keratin-related skin disorders
Mariposa Therapeutics is a Welsh preclinical biopharma company developing disease-modifying treatments for epidermolysis bullosa simplex and other keratin-related skin disorders.…
Global biopharma with UK R&D hub in Hertfordshire
Roche Products is the UK pharmaceutical arm of F. Hoffmann-La Roche, headquartered at Welwyn Garden City in Hertfordshire. The site employs over 1,900 people and serves as a…
AI platform engineering molecular glue drugs for undruggable targets
Ternary Therapeutics is a preclinical-stage biotechnology company developing an AI-driven platform for the rational design of molecular glue therapeutics. Molecular glues are…
Circadian hormone therapeutics for rare endocrine conditions
Neurocrine UK is the European operations of Neurocrine Biosciences, a Cardiff-headquartered specialty pharmaceutical company developing and commercialising hormone therapeutics…