Discover life science companies across the East of England, including biotechnology firms, CROs, research organisations and innovation hubs.
First-in-class small molecule inhibitors of RNA-modifying enzymes
STORM Therapeutics is a clinical-stage biotechnology company pioneering the field of RNA epigenetics, developing small molecule inhibitors of RNA-modifying enzymes as a new class of cancer treatment. Its lead programme STC-15, a METTL3 inhibitor, was the first RNA-modifying enzyme inhibitor to enter human clinical…
Cancer genetics testing and contract research
Oncologica provides molecular cancer diagnostics and contract research services from its laboratory at Chesterford Research Park near Cambridge. Its Oncofocus testing uses tumour DNA profiling to help clinicians identify potentially relevant targeted treatments and immunotherapies. The company also develops…
Targeted protein degradation platform for neurodegenerative disease
TRIMTECH Therapeutics is a biotechnology company developing small-molecule degraders that selectively remove disease-causing protein aggregates while preserving the functional, non-aggregated forms of the same proteins. The platform is built on research into the E3 ubiquitin ligase TRIM21, conducted over nearly two…
AI bioprocess operating system for cell and gene therapy manufacturing
Native Labs Ltd is a software company developing an AI-powered bioprocess operating system for cell and gene therapy manufacturing. The platform unifies heterogeneous manufacturing data, including bioreactor time series, multi-omics, and batch records, into standardised AI-ready datasets. Neural network models enable…
Rapid diagnostic platforms for infectious disease and consumer testing
Sapphiros is a privately held diagnostics portfolio company backed by KKR and Neoenta. UK operations include Biocrucible, a molecular diagnostics company developing ultra-rapid isothermal nucleic acid amplification assays, and an Extreme Volume Manufacturing capability producing lateral flow diagnostic tests at…
Life sciences membership organisation and industry network
One Nucleus is a not-for-profit life sciences and healthcare membership organisation headquartered in Cambridge, serving over 400 member companies across the Cambridge/London corridor and beyond. It provides networking events, training, business development support and access to international partnering conferences,…
Tunable covalent chemistry platform for neurodegenerative disease
Dunad Therapeutics is a drug discovery biotech developing small molecule therapies for neurodegenerative diseases including ALS, frontotemporal dementia, and Parkinson's disease. Its platform combines tunable covalent chemistry with targeted protein degradation, using monovalent small molecules that form durable bonds…
Recombinant proteins and custom protein production for researchers
Cambridge Protein Works supplies purified recombinant proteins and custom production services to academic and industrial researchers. Its catalogue includes specialist protein reagents, while bespoke services accommodate specific protein variants and experimental requirements. The company also prepares samples for…
Antibody therapy to deplete amyloid deposits in ATTR cardiomyopathy
Immutrin is a biotechnology company developing an engineered antibody therapeutic designed to actively remove amyloid deposits from tissues in patients with amyloidosis. Its lead asset targets ATTR cardiomyopathy, a progressive and often fatal cardiac disease caused by transthyretin amyloid accumulation, for which no…
International centre of excellence in plant science and microbiology
The John Innes Centre is a research institute conducting fundamental, strategic and applied research in plant science and microbiology. The centre studies plant and microbial genetics, genomics and cell biology, applying techniques including CRISPR gene editing to improve crop resilience and food security. It trains…
Phage-based blood test for tuberculosis and mycobacterial disease
PBD Biotech is a diagnostics company that develops phage-based blood and milk tests for detecting active mycobacterial infections, including bovine tuberculosis, Johne's disease and human tuberculosis. Its proprietary technology uses bacteriophages to selectively infect live mycobacteria, enabling rapid, accurate…
Synthetic plant metabolites for osteoarthritis and age-related disease
AKL Therapeutics is a privately held UK pharmaceutical company developing APPA, a patented oral investigational medicine combining two synthetic plant metabolites that act synergistically to target multiple signalling pathways in osteoarthritis. Animal studies have demonstrated pain reduction and delayed cartilage…
In vivo cell reprogramming therapies for degenerative disease
Mogrify is a biotechnology company developing a novel class of in vivo reprogramming therapies for degenerative diseases. Its proprietary platforms use large-scale transcriptomic and epigenomic network data to predict the transcription factors required to convert mature human cells directly into target therapeutic…
UK trade body for the industrial bioeconomy
The Bio-based and Biodegradable Industries Association (BBIA) is the UK membership organisation representing companies involved in the production, processing, and distribution of bio-based, biodegradable, and compostable materials and chemicals. It advocates for policy frameworks that accelerate adoption of industrial…
Cell rejuvenation to reverse disease and age-related disability
Altos Labs studies cellular rejuvenation, aiming to restore cell resilience and understand biological processes underlying disease, injury and ageing. Its international research institutes combine experimental biology, computational science and therapeutic development. Research includes cellular reprogramming and…
Next-generation targeted protein degradation therapeutics
Amphista Therapeutics is a Cambridge-based biopharmaceutical company developing next-generation targeted protein degradation medicines. Its proprietary platform generates bifunctional small molecule degraders that harness a broader range of the cell's protein-degrading machinery than existing approaches, enabling…
Plant-based molecular farming platform for bio-identical collagen production
LeafyColl is a biotech developing a molecular farming platform for the scalable, plant-based production of bio-identical human collagen and other specialty proteins. The system uses engineered plants as programmable bio-factories to produce high-purity collagen for applications spanning regenerative medicine, wound…
Programmable RNA for scalable cell engineering and biomanufacturing
Plurify is a biotechnology company developing PluRNA, a programmable RNA platform for sustained protein expression without genome integration. Its technology is designed to engineer cells through controllable RNA-based programmes, with applications in stem-cell therapy manufacturing, cell purification, biologics…
UK distributor of analytical instruments for life science laboratories
Verulam Scientific is a specialist distributor of analytical instruments and laboratory systems serving the UK pharmaceutical, clinical, life science, environmental, and biotechnology markets. The company represents a portfolio of European and US manufacturers, supplying and supporting systems in HPLC electrochemical…
Instrument-free single-cell RNA sequencing kits for scalable genomic analysis
CS Genetics is a genomics tools company developing instrument-free reagent kits for single-cell transcriptomics. Its platform uses a proprietary process in which bifunctional bead reagents pair with individual cells through stoichiometric geometry, enabling single-cell RNA sequencing in standard laboratory plasticware…