Protein engineering companies design and modify proteins to improve their activity, stability, selectivity and suitability for specific applications. These technologies support therapeutic development, industrial biotechnology, diagnostics and the creation of improved enzymes and research tools.
This category includes companies working on:
Browse 98 UK protein engineering companies below.
Nanopore platform for single-molecule full-length protein sequencing
Portal Biotech is a biotechnology company developing benchtop nanopore instruments for single-molecule proteomics and metabolomics. Its platform uses bioengineered nanopores coupled with machine learning to sequence intact, full-length proteins at the single-molecule level, capturing protein mutations, modifications…
ML-guided strain engineering to optimise precision fermentation yields
Eden Genetics is a biotechnology company using machine learning to improve recombinant protein production through microbial strain engineering. Its computational platform analyses genetic and fermentation data to identify modifications intended to increase protein secretion and productivity in precision-fermentation…
AI-driven enzyme discovery for sustainable industrial ingredients
Scindo is a UK biotechnology company developing an AI-powered enzyme discovery and engineering platform to produce bio-based alternatives to petroleum-derived industrial ingredients. The company combines machine learning with proprietary experimentally validated reaction datasets to discover and optimise enzymes…
Mammalian recombinant protein production and cell line development services
Daresbury Proteins is a contract research organisation specialising in mammalian recombinant protein production and cell line development. Using proprietary expression vectors optimised for CHO-K1 and HEK293 systems, the company produces difficult-to-express proteins as research reagents and candidate targets for…
Generative AI and quantum chemistry platform for de novo enzyme design
Xyme is a biotechnology company developing a generative AI and quantum chemistry platform for designing novel enzymes from first principles. Its approach combines computational prediction with experimental validation to create enzymes that catalyse chemical reactions not found in nature. Applications span therapeutic…
Medical-grade collagen biomaterials for regenerative medicine devices
Evergen develops, manufactures, and supplies medical-grade collagen biomaterials and engineered tissue scaffolds for use in medical devices and regenerative medicine. Operating from Glasgow under GMP conditions, the company partners with OEM medical device manufacturers to develop and supply collagen formulations…
Precision fermentation platform producing animal-free dairy proteins
Better Dairy is a biotechnology company using precision fermentation to produce animal-free dairy proteins including casein and osteopontin. By engineering yeast to express mammalian milk proteins, the company produces bioidentical ingredients that enable food manufacturers to make dairy products without livestock.…
Carbohydrate binding molecules targeting the tumour glycome in cancer
Omideon is a Scottish preclinical biotechnology company applying multivalent carbohydrate binding molecule (mCBM) technology to oncology. Spun out from Pneumagen Limited by demerger in 2020, the company uses genetic engineering to develop mCBMs with high affinity for tumour-associated terminal glycans. Its lead…
AI-driven T-cell receptor discovery platform for solid tumour immunotherapies
Exogene is an Oxford biotech developing TCR-based immunotherapies for solid tumours. Its platform integrates generative AI, biophysical simulation, and high-throughput TCR-antigen screening to identify rare, high-affinity cancer-specific T-cell receptors from patient tumour samples. The company develops TCR-T cell…
Molecular farming platform producing specialty proteins from crop leaves
Kyomei is a biotechnology company developing a molecular farming platform that genetically engineers crop plants to produce high-value specialty proteins in their leaves. The company extracts these proteins from agricultural leaf waste that would otherwise be discarded at harvest. Kyomei's ingredients target food…
Engineered bacterial protein polymers for cell culture and cultivated meat
MarraBio is a biotechnology company developing engineered Caf1-based protein polymers as xeno-free, thermostable alternatives to extracellular matrix proteins and growth factors used in mammalian cell culture. Its proprietary platform enables scalable, cost-effective production of multifunctional materials that…
Custom recombinant antibody and protein development services
Scotia Biologics is a contract research organisation specialising in custom antibody and recombinant protein development for biomedical researchers and diagnostic developers. Services span antigen design, polyclonal and monoclonal antibody generation via hybridoma and phage display, antibody engineering including…
Tumour-activated peptide drug conjugates for targeted oncology
Avacta Therapeutics is a clinical-stage biotechnology company developing peptide drug conjugates designed to deliver toxic chemotherapy payloads selectively within the tumour microenvironment. The company's delivery approach uses a short engineered peptide that masks the active payload until it is cleaved by…
Plant-based expression platform for recombinant protein production
Bright Biotech is a UK CDMO developing and applying a proprietary plant-based expression system for the production of recombinant proteins. Its platform uses chloroplast engineering in tobacco plants to express high yields of target proteins, offering an animal-free and scalable alternative to conventional cell-based…
Engineering biology CRDMO for pharma and industrial biotech
Ingenza is a contract research, development, and manufacturing organisation applying engineering biology to solve manufacturing challenges across pharmaceuticals and industrial biotechnology. The company provides strain and cell line engineering, fermentation, bioprocess development, and analytical services for…
Developing cell-free long-DNA manufacturing for precision breeding
Newcleic develops cell-free methods for manufacturing long DNA sequences, drawing on biochemical engineering research at UCL. Its technology aims to make complex DNA production more reliable, accessible and sustainable. Its initial focus is agricultural biotechnology, supporting precision breeding and plant…
AI-enabled biologics discovery and therapeutic development
Divergence Labs develops new medicines by combining molecular engineering, machine learning and high-throughput biological experimentation. Its Cambridge research team integrates antibody and biologics discovery, cell engineering and automated screening to identify and optimise therapeutic candidates. Proprietary…
Yeast strain engineering platform for recombinant protein biomanufacturing
Phenotypeca is a synthetic biology company that engineers baker's yeast strains for the production of recombinant proteins, biosimilars, and vaccine antigens. Using proprietary quantitative trait loci technology, the company generates and screens large libraries of yeast variants to identify production strains with…
Precision fermentation platform for novel protein-based flavour ingredients
ReNewFood is an industrial biotech developing protein-based flavouring ingredients for the alternative food market using precision fermentation. Engineered microbial hosts serve as cell factories to produce flavour-active proteins, including molecules conferring meatiness, sweetness, and saltiness, identified through…
AAV gene therapies for rare and neurological diseases
Spur Therapeutics is a clinical-stage biotechnology company developing adeno-associated virus-based gene therapies for serious chronic diseases. Its lead programme is a Phase I/II gene therapy for Gaucher disease type 1, a rare lysosomal storage disorder. Further pipeline candidates target GBA1 Parkinson's disease and…