Protein engineering companies design and modify proteins to improve their activity, stability, selectivity and suitability for specific applications. These technologies support therapeutic development, industrial biotechnology, diagnostics and the creation of improved enzymes and research tools.
This category includes companies working on:
Browse 98 UK protein engineering companies below.
Global drug discovery and development partnership company
Evotec is a global drug discovery and development company with major UK operations at Milton Park, Abingdon, and Alderley Park, Cheshire. Its Abingdon campus houses over 800 staff spanning target validation, medicinal chemistry, structural biology, in silico design, process development, and biologics manufacturing…
Cell-penetrating peptide reagents for intracellular research applications
Cupid Peptides is a Cardiff-based manufacturer of cell-penetrating peptide products for biomedical research. Its proprietary Cupid sequence, derived from the amoeba Dictyostelium discoideum, enables large recombinant protein cargoes to traverse cell membranes and access intracellular targets. Products offer the…
Recombinant antibodies developed using display technology platforms
Tresars is a developer and manufacturer of synthetic, non-animal-derived recombinant antibodies for life science research. Using phage, yeast, mRNA, and ribosome display technologies, the company selects and affinity-matures antibody clones against customer-specified protein targets without animal immunisation.…
Integrated academic drug discovery facility for anti-infectives and innovative targets
The Drug Discovery Unit is an academic drug discovery facility at the University of Dundee, integrating medicinal chemistry, high-throughput screening, structural biology, cell biology, and DMPK in a single purpose-built facility. The DDU conducts small molecule drug discovery programmes across two areas:…
Therapeutic cancer vaccines based on recombinant overlapping peptide technology
Oxford Vacmedix is a clinical-stage biopharma company developing therapeutic cancer vaccines using its proprietary Recombinant Overlapping Peptide (ROP) platform. ROPs stimulate broad T cell and antibody immunity without HLA restriction, enabling a universal immunotherapy approach. The lead programme, OVM-200, targets…
Global bioprocess technology and life science tools provider
Cytiva is a global life sciences company providing technologies, instruments and services for biopharmaceutical research, development and manufacturing. Its UK operations span multiple sites including Amersham (protein analysis, Western blotting), Cardiff (single-use bioprocessing manufacturing, genomics R&D, magnetic…
Programmable synthetic organelle tools for protein expression and purification
Ailurus is a synthetic biology company that develops programmable biological systems and sells them as research tools to life science customers. Its current product uses synthetic membraneless organelles engineered through genetic code to streamline protein expression and purification in bacterial hosts, reducing…
Multiplexed imaging platform for therapeutic mechanism of action discovery
Micrographia Bio is a biotechnology company developing a spatial proteomics platform for drug discovery. Its technology combines highly multiplexed microscopy with machine-intelligent computer vision to autonomously determine the mechanism of action of therapeutic candidates by visualising protein-protein interactions…
High-capacity viral vector manufacturing platform for gene therapy
Icosphere Biosciences is a biotechnology company developing manufacturing technology for high-capacity gene therapy vectors. Its platform enables scalable, high-yield, contamination-free production of high capacity adenoviral vectors capable of carrying substantially more genetic material than conventional viral…
High-throughput protein stability screening by differential scanning fluorimetry
Protein Stable is a UK instrumentation company developing high-throughput fluorescence systems for protein stability screening. Its SUPR-DSF and SUPR-CM platforms measure thermal and chemical unfolding in microplates, supporting biologics formulation, protein engineering and drug discovery. The technology uses…
Enzyme engineering platform for sustainable biomanufacturing of natural ingredients
Pathfinder Bio is a UK-based biotechnology company developing an enzyme discovery and engineering platform for sustainable chemical manufacturing. Using ultra-high-throughput screening of engineered bacterial cells, the company measures the performance of billions of enzyme variants to design optimised biocatalytic…
Spider-inspired protein fibre spinning for sustainable and biocompatible materials
Spintex Engineering is a developer of bioinspired silk fibres, produced from a liquid protein feedstock using a spider-inspired self-assembly process. The technology requires no hazardous chemicals, with water as the only by-product, and is significantly more energy efficient than synthetic fibre production. Spintex's…
Chromatography resins and bioseparation technologies for biomanufacturing
Astrea Bioseparations develops and manufactures chromatography resins, adsorbents, columns and nanofiber-based purification technologies for the biopharmaceutical and advanced therapeutics industries. Its portfolio supports downstream bioprocessing including affinity purification, host cell protein removal, viral…
Multimodal engineered T-cell therapies for treatment-refractory solid cancers
Alceus Bio is a biotechnology company developing next-generation engineered T-cell therapies for solid tumours. Its platform uses generative AI and synthetic biology to design therapeutic proteins that patient-derived immune cells are programmed to express and deliver in situ, targeting intracellular disease drivers…
Engineered hybrid interferon therapeutics for viral and immune-mediated disease
ILC Therapeutics is a pre-clinical biotechnology company developing hybrid interferons, an engineered cytokine drug class combining favourable attributes of multiple naturally occurring interferon subtypes. The platform rationally designs novel candidates with reduced toxicity and pleiotropic activity across multiple…
AI platform designing vaccines against current and future pathogens
Baseimmune is a biotechnology company developing a deep learning platform for computational vaccine antigen design. The platform integrates genomic, epidemiological, immunological, and evolutionary data to generate novel synthetic antigens drawn from across an entire pathogen genome, enabling the design of vaccines…
Modular microfluidic and automation systems for autonomous biology labs
Engivent develops modular microfluidic hardware and automation software for biological laboratories. Its platform combines microfluidic chips, laboratory robotics, sensing and structured data capture into programmable experimental workflows. The company is building towards closed-loop systems in which results inform…
Proprietary phage display platform for therapeutic antibody discovery
RxBiologics is a Cambridge-based antibody discovery CRO and subsidiary of RxCelerate. Its proprietary phage display library platform incorporates in-line optimisation technology modelled on B cell affinity maturation, designed to generate clinic-ready antibody candidates with drug-like properties from first selection.…
Small molecule remyelination therapeutics for neurological diseases
Pheno Therapeutics is a Scottish clinical-stage biotechnology company developing small molecule therapeutics that promote remyelination by boosting the function of oligodendrocytes in the central nervous system. Its lead programme PTD802, a selective GPR17 antagonist licensed from UCB, received MHRA clinical trial…
AI-driven drug discovery targeting intrinsically disordered proteins
Peptone is a translational biophysics company developing novel therapeutics against intrinsically disordered proteins (IDPs), a class of structurally dynamic proteins implicated in cancer, inflammation and metabolic disease. The company combines hydrogen-deuterium exchange mass spectrometry, high-performance…