Protein engineering companies design and modify proteins to improve their activity, stability, selectivity and suitability for specific applications. These technologies support therapeutic development, industrial biotechnology, diagnostics and the creation of improved enzymes and research tools.
This category includes companies working on:
Browse 98 UK protein engineering companies below.
Engineered biologics with conditional activation for precision cancer immunotherapy
Switch Biologics is a UK biotechnology company developing engineered protein biologics for cancer immunotherapy. The company applies directed evolution and protein engineering to build conditionally activated therapeutics that respond to two simultaneous molecular signals, a design intended to concentrate activity…
ML-driven antibody discovery platform for solid tumour therapeutics
LabGenius Therapeutics is a company developing next-generation therapeutic antibodies using its closed-loop machine learning platform. The platform integrates AI, robotic automation and high-throughput experimentation to co-optimise multispecific antibodies across potency, selectivity and manufacturability…
Engineered therapeutic red blood cells for rare metabolic and other diseases
Scarlet Therapeutics is a biotechnology company developing a platform for generating therapeutic red blood cells (tRBCs). Erythroid cell lines are genetically engineered to produce red blood cells carrying high concentrations of therapeutic proteins, exploiting their natural tissue distribution, 120-day circulating…
Enzyme-based platform for sustainable industrial chemical manufacture
HydRegen is a biotechnology company developing enzyme immobilisation platforms that replace heavy-metal catalysts in redox and hydrogenation reactions. The technology uses hydrogen gas to power NADH-dependent enzymes on carbon supports, enabling continuous flow processing of fine chemicals and active pharmaceutical…
Targeted lipid nanoparticle delivery platform for precision therapeutics
Hone Bio is a preclinical biotechnology company developing targeted lipid nanoparticle drug delivery technology. Its proprietary platform uses engineered proteins that enable cell-specific LNP delivery while actively blocking off-target liver uptake, addressing a key limitation of conventional LNP systems. The…
Recombinant proteins and custom protein production for researchers
Cambridge Protein Works supplies purified recombinant proteins and custom production services to academic and industrial researchers. Its catalogue includes specialist protein reagents, while bespoke services accommodate specific protein variants and experimental requirements. The company also prepares samples for…
Antibody therapy to deplete amyloid deposits in ATTR cardiomyopathy
Immutrin is a biotechnology company developing an engineered antibody therapeutic designed to actively remove amyloid deposits from tissues in patients with amyloidosis. Its lead asset targets ATTR cardiomyopathy, a progressive and often fatal cardiac disease caused by transthyretin amyloid accumulation, for which no…
AI-driven enzyme engineering platform for pharmaceutical manufacturing
Imperagen is a biotechnology company developing an automated enzyme engineering platform that combines AI-powered protein design with synthetic biology and laboratory automation. The company engineers optimised biocatalysts for pharmaceutical manufacturing, enabling greener and more efficient production of complex…
Next-generation targeted protein degradation therapeutics
Amphista Therapeutics is a Cambridge-based biopharmaceutical company developing next-generation targeted protein degradation medicines. Its proprietary platform generates bifunctional small molecule degraders that harness a broader range of the cell's protein-degrading machinery than existing approaches, enabling…
Plant-based molecular farming platform for bio-identical collagen production
LeafyColl is a biotech developing a molecular farming platform for the scalable, plant-based production of bio-identical human collagen and other specialty proteins. The system uses engineered plants as programmable bio-factories to produce high-purity collagen for applications spanning regenerative medicine, wound…
Integrated bioprocessing technologies, consumables and services for biopharma
Sartorius Stedim Biotech is a global supplier of bioprocessing technologies, filtration systems, single-use solutions and laboratory instruments for the biopharmaceutical industry. Its UK operations span manufacturing, commercial and contract testing functions, including sites in Stonehouse (consumables and single-use…
Collagen-based biomaterials as sustainable alternatives to leather
PACT Earth is a UK biotechnology company developing collagen-based biomaterials for the fashion and textiles industries. Its flagship material is produced from ethically sourced collagen derived from freshwater fish farming by-products, processed without synthetic plastics or harsh chemicals. PACT targets brand…
Academic protein informatics and antibody modelling tools
Oxford Protein Informatics Group is a University of Oxford research team led by Professor Charlotte Deane, developing computational methods for protein structures and interactions. Its researchers apply machine learning and bioinformatics to antibody modelling, immunoinformatics, protein engineering and drug…
Computationally designed broadly protective vaccines against pandemic viruses
DIOSynVax is a clinical-stage biotechnology company developing broadly protective vaccines using a computational antigen design platform. The company's technology applies protein structure modelling and immune optimisation to engineer synthetic vaccine antigen payloads targeting conserved regions of viruses, enabling…
Bispecific antibody-drug conjugates for hard-to-treat solid tumours
Valink Therapeutics is a biotechnology company developing next-generation bispecific antibody-drug conjugates and multispecific antibody therapeutics for oncology. Its proprietary discovery platform enables modular assembly of complex antibody formats combining multispecificity, multivalency, and drug conjugation,…
End-to-end lateral flow immunoassay development and manufacturing
Global Access Diagnostics (GADx) is a contract developer and manufacturer of rapid lateral flow immunoassay tests for human, veterinary, and agricultural applications. Operating as a social enterprise, GADx provides end-to-end diagnostic development services from assay design and antibody development through to…
AI-powered drug design engine built on AlphaFold technology
Isomorphic Labs is an artificial intelligence company applying frontier AI to drug discovery, built on and beyond the Nobel Prize-winning AlphaFold protein structure prediction system developed at Google DeepMind. Its proprietary drug design engine spans target identification, molecular design, and binding prediction…
AI-designed enzymes for enzymatic recycling of plastics and textiles
Epoch Biodesign is a London-based industrial biotech developing AI-engineered enzymes for the biorecycling of mixed plastics and textiles. The company's platform uses machine learning to design enzymes that deconstruct waste materials at the molecular level, recovering high-purity chemical building blocks for…
Contract antibody discovery, engineering and supply services
Fusion Antibodies is a contract research organisation specialising in preclinical antibody discovery, engineering and supply for pharmaceutical and diagnostic clients. Services span antigen expression, antibody generation, humanisation, affinity maturation, developability optimisation, and stable cell line…
AI-driven protein interaction modelling for peptide drug discovery
Xenos Bio is developing a computational platform that uses physics-based algorithms integrated with machine learning to predict protein-protein interactions and identify binding motifs within functional protein domains. Its software is deployed for rational peptide library construction, delivering enhanced hit…